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Super-resolution Fluorescence Microscopy

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Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

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Collective localized surface plasmons for high performance fluorescence biosensing.

Martin Bauch, Jakub Dostalek

|October 10, 2013

Summary

This summary is machine-generated.

Metallic nanostructures supporting collective localized surface plasmons (cLSPs) offer significant signal amplification for fluorescence biosensors. These novel cLSP structures can enhance fluorescence intensity by over 1000-fold.

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Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

Area of Science:

Plasmonics
Nanotechnology
Biosensing

Background:

Collective localized surface plasmons (cLSPs) in metallic nanostructures enhance fluorescence.
cLSPs offer lower damping, higher field enhancement, and narrower resonance than regular localized surface plasmons.
Applications in fluorescence biosensors require optimized signal amplification.

Purpose of the Study:

To design and simulate a novel cLSP structure for enhanced fluorescence biosensing.
To investigate the potential of cLSPs for achieving high fluorescence intensity enhancement.
To evaluate cLSP performance in realistic immunoassay scenarios.

Main Methods:

Utilized finite difference time domain (FDTD) simulations to design cLSP structures.
Modeled cLSP excitation, emission, and quantum yield effects.
Simulated surface plasmon-enhanced fluorescence (PEF) in sandwich immunoassays.

Main Results:

Designed a novel cLSP structure with two resonances matching fluorophore wavelengths.
Simulations demonstrated fluorescence intensity enhancement exceeding 10^3.
cLSP-driven excitation, directional emission, and mediated quantum yield were considered.

Conclusions:

cLSP-based nanostructures show exceptional potential for fluorescence biosensor signal amplification.
The designed cLSP structure is promising for next-generation biosensing applications.
This approach could lead to highly sensitive and efficient fluorescence detection methods.