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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
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Pyranonigrin E: a PKS-NRPS hybrid metabolite from Aspergillus niger identified by genome mining
Takayoshi Awakawa1, Xiao-Long Yang, Toshiyuki Wakimoto
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan).
Chembiochem : a European Journal of Chemical Biology
|October 10, 2013
Abstract:
Induced production of PKS-NRPS metabolites: the genome mining approach is useful for obtaining new compounds. We activated a dormant PKS-NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.

