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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Types of RNA

Types of RNA

Types of RNA

Types of RNA

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Related Experiment Video

Updated: May 7, 2026

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

Identification and function of long non-coding RNA.

Carl Ernst¹, Cynthia C Morton

¹Douglas Hospital Research Institute Montreal, QC, Canada ; Department of Psychiatry, McGill University Montreal, QC, Canada.

Frontiers in Cellular Neuroscience

|October 10, 2013

Summary

This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are diverse molecules whose function is not determined by size or sequence. Their genomic position relative to a target is key for function, especially in neurodevelopment.

Keywords:

epigenetics gene regulation neurodevelopment non-coding RNA

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Last Updated: May 7, 2026

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Area of Science:

Molecular Biology
Genomics
Neuroscience

Background:

Long non-coding RNAs (lncRNAs) are a diverse class of RNA molecules distinct from other RNA types.
Recent studies indicate widespread transcription of lncRNAs across the genome, necessitating functional characterization.
Understanding lncRNA function is crucial, particularly for their roles in neurodevelopment.

Purpose of the Study:

To review key issues in the functional assessment of lncRNAs.
To explore the significance of genomic position in lncRNA function.
To discuss the application of these concepts to lncRNAs involved in neurodevelopment.

Main Methods:

Synthesis of recent studies on lncRNA characteristics and function.
Analysis of factors influencing lncRNA functional assessment.
Review of literature on lncRNAs in neurodevelopment.

Main Results:

lncRNA function is independent of size, poly-A tail, splicing, transcription direction, or strand specificity.
The relative genomic position of a lncRNA to its target is fundamentally important for its function.
These findings have implications for understanding lncRNAs in neurodevelopmental processes.

Conclusions:

Functional assessment of lncRNAs should prioritize genomic context over molecular features.
Genomic position is a critical determinant of lncRNA activity.
This understanding is vital for advancing research on lncRNAs in neurodevelopment.