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Updated: May 7, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Dynamic kinetic cross-coupling strategy for the asymmetric synthesis of axially chiral heterobiaryls
Abel Ros1, Beatriz Estepa, Pedro Ramírez-López
1Instituto Investigaciones Químicas (CSIC-US), University of Seville , C/Américo Vespucio, 49, 41092 Sevilla, Spain.
Abstract:
A dynamic kinetic asymmetric transformation (DYKAT) technique has been designed for the synthesis of 2'-substituted 2-aryl pyridines/isoquinolines and related heterobiaryls. In this way, the Pd(0)-catalyzed coupling of racemic 2-triflates with aryl boroxines using a TADDOL-derived phosphoramidite as the ligand provides the corresponding coupling products with good to excellent enantioselectivities. Structural studies support that the formation of configurationally labile oxidative addition palladacycles is the key for the success of the methodology.
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