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Updated: May 7, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

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Published on: December 8, 2023

Neurotrophic keratitis.

F Semeraro¹, E Forbice, V Romano

¹Eye Clinic, Department of Ophthalmology, University of Brescia, Brescia, Italy.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde

|October 11, 2013

Summary

This summary is machine-generated.

Neurotrophic keratitis (NK), a corneal disease from impaired trigeminal nerves, affects corneal sensitivity and healing. This review covers NK causes, diagnosis, and current/future treatments to promote corneal repair.

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Area of Science:

Ophthalmology
Neuroscience
Regenerative Medicine

Background:

Neurotrophic keratitis (NK) results from trigeminal nerve impairment, reducing corneal sensitivity.
This leads to epithelial defects, delayed healing, and stromal edema.
Current understanding focuses on addressing aetiopathogenesis and promoting corneal healing.

Purpose of the Study:

To review the aetiology, diagnosis, and management of neurotrophic keratitis.
To discuss current medical and surgical treatment strategies.
To explore future therapeutic approaches for NK.

Main Methods:

Literature review of recent studies on neurotrophic keratitis.
Analysis of aetiopathogenetic theories and therapeutic interventions.
Synthesis of diagnostic and management guidelines.

Main Results:

NK impairs corneal sensitivity, lacrimation, and epithelial cell vitality.
Deficient epithelial repair, stromal edema, and basal lamina abnormalities are characteristic.
Various therapies target aetiopathogenesis to enhance corneal healing.

Conclusions:

Effective NK management requires addressing underlying causes and promoting healing.
A combination of medical and surgical treatments may be necessary.
Future research holds promise for novel regenerative therapies for NK.