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Analysis of MAT3 gene expression in NSCLC
Shangen Zheng1, Yuwen Du, Heying Chu
1College of Basic Medical Sciences, Zhengzhou University, No,100 Kexue Road, Zhengzhou 450001, China. gjzhangzzu@126.com.
Diagnostic Pathology
|October 11, 2013
Summary
Metastasis-associated protein 3 (MAT3) is overexpressed in non-small cell lung cancer (NSCLC) and predicts lymph node metastasis. MAT3 levels indicate poor survival, identifying high-risk NSCLC patients.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Metastasis-associated protein 3 (MAT3) has varied roles in human cancers.
- MAT3 expression and function in lung cancer remain largely uncharacterized.
Purpose of the Study:
- To investigate MAT3 expression in non-small cell lung cancer (NSCLC).
- To determine the relationship between MAT3 and clinicopathological factors in NSCLC.
- To assess the prognostic value of MAT3 in NSCLC patients.
Main Methods:
- Quantitative real-time RT-PCR and immunohistochemistry were used to detect MAT3 mRNA and protein in 118 NSCLC samples.
- Survival analysis was performed using follow-up data.
- Correlation analysis was conducted between MAT3 expression and clinicopathological characteristics.
Main Results:
- MAT3 mRNA and protein were significantly upregulated in NSCLC tissues compared to non-neoplastic tissues.
- Higher MAT3 expression correlated with lymph node metastasis and poorer survival.
- MAT3 mRNA levels were identified as a risk factor for lymph node metastasis and survival in NSCLC patients.
Conclusions:
- MAT3 is overexpressed in NSCLC and serves as a risk factor for lymph node metastasis.
- MAT3 expression levels (mRNA and protein) are significant predictors of survival in NSCLC patients.
- MAT3 can be a valuable biomarker for identifying high-risk NSCLC patients.
