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Association of a prothrombotic state with left-ventricular diastolic dysfunction in hypertension: a tissue-Doppler

Cristiana Catena1, GianLuca Colussi, Stefania Fedrizzi

  • 1Hypertension Unit, Internal Medicine, Department of Experimental and Clinical Medical Science, University of Udine, Udine, Italy.

Journal of Hypertension
|October 11, 2013
PubMed

Insights

In hypertensive patients, elevated fibrinogen and a prothrombotic state are linked to left-ventricular diastolic dysfunction. This finding may increase the risk of diastolic heart failure in those without ischemic heart disease.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Hypertension contributes to organ damage, influenced by prothrombotic states.
  • Left-ventricular diastolic dysfunction is a key indicator of cardiac health in hypertensive individuals.

Purpose of the Study:

  • To investigate the association between an activated hemostatic system and left-ventricular diastolic dysfunction in hypertensive patients.
  • To assess diastolic dysfunction using tissue-Doppler imaging (TDI).

Main Methods:

  • 198 patients with untreated essential hypertension were studied.
  • Plasma levels of fibrinogen, prothrombin fragment 1+2, D-dimer, PAI-1, and t-PA were measured.
  • Conventional echocardiography and TDI were performed.

Main Results:

  • Left-ventricular diastolic dysfunction was identified in 53% of patients by TDI.
  • Diastolic dysfunction correlated with older age, higher BMI, SBP, left-ventricular mass index, and elevated plasma fibrinogen and D-dimer.
  • TDI-assessed diastolic function remained associated with plasma fibrinogen levels independently of other factors.

Conclusions:

  • Elevated plasma fibrinogen and a prothrombotic state are associated with left-ventricular diastolic dysfunction in hypertensive patients.
  • These hemostatic factors may elevate the risk of developing diastolic heart failure.
  • Findings highlight the importance of assessing hemostatic markers in hypertensive patients with diastolic dysfunction.
Abstract

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