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Atazanavir and chest pain
Matthew Phillips1, Cara Saxon, Vincent Lee
1Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
International Journal of STD & AIDS
|October 11, 2013
Summary
Chest pain in a patient on antiretrovirals resolved after stopping atazanavir and ritonavir. This highlights the importance of monitoring cardiovascular risks associated with protease inhibitor therapy.
Area of Science:
- Cardiology
- Pharmacology
- Infectious Diseases
Background:
- Antiretroviral therapy (ART) is crucial for managing HIV infection.
- Protease inhibitors (PIs) are a key class of antiretrovirals.
- Cardiovascular risks are a known concern with some ART regimens.
Observation:
- A 41-year-old man experienced chest pain.
- The patient directly linked the chest pain to his antiretroviral medications, specifically atazanavir and ritonavir.
- Symptoms resolved upon treatment cessation and reappeared upon restarting atazanavir.
Findings:
- The case suggests a potential link between atazanavir use and the development of chest pain.
- Cessation and reintroduction of atazanavir correlated directly with symptom resolution and recurrence.
- This observation aligns with reported associations between atazanavir and cardiac arrhythmias.
Implications:
- Cardiovascular risk assessment is essential for patients on antiretroviral therapy, especially PIs.
- Electrocardiogram (ECG) monitoring may be advisable for patients initiating or using atazanavir-based regimens.
- Further investigation into the cardiac safety profile of atazanavir is warranted.
Keywords:
HAART (highly active antiretroviral therapy)HIV (human immunodeficiency virus)anginaarrhythmiaatazanavircardiovascularprotease inhibitortoxicityMore Related Videos
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