Related Experiment Video
Updated: May 7, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
N-(3-Meth-oxy-benzo-yl)-2-methyl-benzene-sulfonamide
S Sreenivasa1, D Darshan, M Prakash Shet
1Department of Studies and Research in Chemistry, Tumkur University, Tumkur, Karnataka 572 103, India.
Abstract:
In the title compound, C15H15NO4S, the dihedral angle between the methyl- and meth-oxy-substituted benzene rings is 88.99 (12)°. An intra-molecular C-H⋯O hydrogen bond occurs. In the crystal, adjacent mol-ecules form inversion-related dimers through strong N-H⋯O hydrogen bonds, generating R 2 (2)(8) loops. The dimers are further connected through C-H⋯O inter-actions that form C(8) chains parallel to (001). Mol-ecules are also connected through other C-H⋯O hydrogen bonds along the b axis, forming additional C(8) chains. Two aromatic π-π stacking inter-actions [centroid-centroid separations = 3.6150 (1) and 3.6837 (1) Å] generate a three-dimensional architecture.
Related Concept Videos
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Nomenclature of Aromatic Compounds with a Single Substituent
NMR Spectroscopy of Benzene Derivatives
Nomenclature of Aromatic Compounds with Multiple Substituents
For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...
Preparation and Reactions of Sulfides
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...

