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Updated: May 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
(2E)-3-(2-Chloro-8-methyl-quinolin-3-yl)-1-(2-methyl-4-phenyl-quinolin-3-yl)prop-2-en-1-one
R Prasath1, S Sarveswari, Seik Weng Ng
1Department of Chemistry, BITS, Pilani - K. K. Birla Goa Campus, Goa 403 726, India.
Abstract:
In the title compound, C29H21ClN2O, there is a twist in the bridging prop-2-en-1-one group [C=C-C=O torsion angle = 22.7 (2)°]. The quinolinyl residues form a dihedral angle of 86.92 (4)°, indicating an almost perpendicular relationship. In the crystal, supra-molecular layers in the bc plane are stabilized by C-H⋯π and π-π inter-actions [centroid-centroid distance = 3.4947 (7) Å].
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