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Updated: May 7, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
2-[4-(2-Chloro-acet-yl)phen-yl]-2-methyl-1-(pyrrolidin-1-yl)propan-1-one
1Security and Environment Engineering College, Capital University of Economics and Business, Beijing 10070, People's Republic of China.
Abstract:
The asymmetric unit of the title compound, C16H20ClNO2, contains two mol-ecules in which the dihedral angles between the benzene ring and the plane of the amide unit are 77.4 (1) and 81.1 (1)°. In both mol-ecules, the five-membered ring adopts an envelope conformation with one of the β-C atoms as the flap. In the crystal, mol-ecules are connected via C-H⋯O hydrogen bonds, forming chains along the b-axis direction. These chains are further linked by C-H⋯π inter-actions, forming a three-dimensional network.
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