The barriers to clinical application of non-invasively obtained central blood pressure

With the demonstration of superior prognostic value of central blood pressure (CBP) beyond traditionally used brachial BP, there have been increasing interest in the development of novel devices reporting parameters of CBP. The emerging devices for non-invasive estimation of CBP, based on either tonometry-based or cuff-based techniques, were evaluated with various validation studies. Therefore, the research community and clinicians have been faced with challenges regarding the conduction and interpretation of the validation studies for the non-invasively obtained CBP. We summarize here the barriers to the clinical application of the CBP concept, which provide research opportunities to further the subsequent translation.