Automated detection of cross-frequency coupling in the electrocorticogram for clinical inspection

We developed a toolbox for detecting high-frequency oscillations and evaluating cross-frequency phase-amplitude coupling in electrocorticographic (ECoG) data with optimal parameters. Here we demonstrate use of the toolbox using simulated and realistic ECoG data. The results confirmed its potential usefulness for clinical research or practice. The tools have been released as a Phase-Amplitude Coupling Toolbox (PACT) plug-in for EEGLAB, an open software environment for electrophysiological data analysis (sccn.ucsd.edu/eeglab).