Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

6.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.1K
Cell Migration01:09

Cell Migration

16.6K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
16.6K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

5.0K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
5.0K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.9K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.9K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.8K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.8K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

2.5K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomic and functional profiling of human intestinal organoids identifies enhanced calcium signalling and thrombospondin-2 activity in cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

Protocol for the INterstitial lung Disease EXacerbations (INDEX) Study: a retrospective multicentre cohort study.

BMJ open respiratory research·2026
Same author

Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration.

Disease models & mechanisms·2026
Same author

Pulmonary cystic destruction in systemic sclerosis and antisynthetase syndrome associated non-specific interstitial pneumonitis: a case series of a novel radiological phenotype.

Rheumatology advances in practice·2026
Same author

Validation of pre-flight algorithms in predicting hypoxic challenge testing (HCT) outcomes in interstitial lung disease (ILD).

Therapeutic advances in respiratory disease·2026
Same author

Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages.

Science advances·2026
Same journal

Analysis of End-Tidal CO2 Variability During Plateau Waves Episodes: An Information Theoretic Approach<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

AI and Tomosynthesis for Breast Cancer Molecular Subtyping: A step toward precision medicine<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Towards Sustainable Protein Recovery from Biological Waste: Assessing Polyethersulfone-based Microfiltration.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of the cardiovascular response to standardized polymicrobial peritonitis experimental model.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Automated Wrist Ultrasound Image Bone Enhancement and Segmentation Using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

A Deep Learning approach for Depressive Symptoms assessment in Parkinson's disease patients using facial videos.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
See all related articles

Related Experiment Video

Updated: May 7, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

16.3K

A Bayesian framework for identifying cell migration dynamics.

Geoffrey R Holmes, Sean R Anderson, Giles Dixon

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 11, 2013
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a new framework using Approximate Bayesian Computation to estimate cell migration dynamics. The method models white blood cell movement during inflammation, applicable to zebrafish neutrophils and general migration scenarios.

    More Related Videos

    Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
    11:43

    Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

    Published on: April 3, 2015

    8.0K
    Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos
    11:39

    Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos

    Published on: April 29, 2016

    7.1K

    Related Experiment Videos

    Last Updated: May 7, 2026

    Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
    07:27

    Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

    Published on: May 13, 2012

    16.3K
    Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
    11:43

    Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

    Published on: April 3, 2015

    8.0K
    Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos
    11:39

    Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos

    Published on: April 29, 2016

    7.1K

    Area of Science:

    • Immunology
    • Biophysics
    • Computational Biology

    Background:

    • Cell migration is crucial for biological processes, including immune responses.
    • Neutrophil migration during inflammation is a key aspect of the innate immune system.
    • Drift-diffusion models are used to simulate population migration, but parameter estimation is challenging, especially with time-varying and non-uniform cell properties.

    Purpose of the Study:

    • To develop a novel framework for estimating cell migration dynamics.
    • To address challenges in data-driven parameter estimation for drift-diffusion models with heterogeneous cell populations.
    • To provide a method applicable to various migration scenarios, including inflammatory responses.

    Main Methods:

    • Utilized Approximate Bayesian Computation (ABC) for parameter estimation and model selection.
    • Developed a novel computational framework to analyze migration dynamics.
    • Applied the framework to model zebrafish neutrophil migration.

    Main Results:

    • Successfully applied the novel framework to estimate zebrafish neutrophil migration dynamics.
    • Demonstrated the framework's capability in handling complex migration scenarios with time-varying properties.
    • The approach facilitates data-driven parameter estimation for drift-diffusion models.

    Conclusions:

    • The proposed framework offers a robust method for analyzing and estimating cell migration dynamics.
    • The approach is versatile and can be applied to diverse biological migration processes.
    • This work advances the understanding of immune cell migration and provides a tool for future research.