Needle-free interstitial fluid acquisition using a Lorentz-force actuated jet injector

Area of Science:

• Biomedical Engineering
• Fluid Dynamics
• Biosampling Technology

Background:

• Interstitial fluid (ISF) sampling is crucial for diagnostics.
• Existing methods can be invasive or time-consuming.
• Needle-free technologies offer potential for less invasive biosampling.

Purpose of the Study:

• To demonstrate the feasibility of a Lorentz-force actuated needle-free jet injector for rapid ISF acquisition.
• To optimize injection and extraction parameters for ISF collection.
• To evaluate the efficiency and consistency of the novel ISF sampling method.

Main Methods:

• Utilized a Lorentz-force actuated needle-free jet injector on ex vivo porcine tissue.
• Employed physiological saline injection to breach the skin barrier.
• Leveraged actuator back-drivability to generate vacuum for ISF collection.
• Optimized injection and extraction parameters to minimize sample dilution and ensure volume consistency.

Main Results:

• Successfully demonstrated the feasibility of rapid ISF acquisition using the needle-free jet injector.
• Achieved ISF sample collection within 3.1 seconds.
• Collected samples containing up to 3.5% ISF, indicating efficient extraction.
• Optimized parameters led to consistent extracted volumes and minimized dilution.

Conclusions:

• The developed Lorentz-force jet injector provides a feasible and rapid method for acquiring interstitial fluid samples.
• This needle-free approach offers a promising alternative for minimally invasive biosampling.
• Further research can explore in vivo applications and broader clinical utility.