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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
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CMOS capacitive biosensors for highly sensitive biosensing applications.

An-Yu Chang, Michael S-C Lu

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    Summary
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    This study developed an integrated lab-on-chip platform using electromagnetic microcoils and capacitive biosensors on a complementary metal oxide semiconductor (CMOS) chip for magnetic microbead manipulation and detection without external equipment.

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    Area of Science:

    • Biotechnology and Biomedical Engineering
    • Microfluidics and Lab-on-Chip Technology
    • Biosensing and Bioelectronics

    Background:

    • Magnetic microbeads are essential tools in biotechnology and biomedical research for cell and biomolecule manipulation and detection.
    • Existing lab-on-chip systems often require external instruments, increasing system size and cost.
    • Integrated platforms are needed to combine manipulation and detection functionalities efficiently.

    Purpose of the Study:

    • To develop an integrated lab-on-chip platform for simultaneous manipulation and detection of magnetic microbeads.
    • To implement electromagnetic microcoils and capacitive biosensors on a complementary metal oxide semiconductor (CMOS) chip.
    • To demonstrate a cost-effective and compact solution for microbead-based assays.

    Main Methods:

    • Fabrication of an integrated platform on a CMOS chip featuring electromagnetic microcoils and capacitive biosensors.
    • Utilizing functionalized anti-streptavidin antibodies to capture streptavidin-coated magnetic microbeads.
    • Employing a capacitance-to-frequency readout for single microbead detection.
    • Comparing experimental results with a control group.

    Main Results:

    • Successful manipulation and detection of single magnetic microbeads on the integrated chip.
    • Demonstrated detection without the need for externally applied magnetic fields.
    • Observed significant average capacitance changes (-5.3 fF) in the experimental group compared to the control group (-0.2 fF).

    Conclusions:

    • The developed integrated platform offers a novel approach for magnetic microbead manipulation and detection.
    • The CMOS-based system provides a compact, cost-effective, and efficient solution for lab-on-chip applications.
    • This technology has potential applications in various biomedical and biotechnological fields requiring sensitive detection and manipulation of biomolecules.