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Delusions of infestation treated with pimozide: a follow-up study
Abstract:
Fourteen patients with monosymptomatic delusions of infestation were followed-up 19-48 months after treatment with pimozide was terminated. Seven patients had remained in remission since the treatment. Three had developed relapses, but were without symptoms with intermittent treatment. Four patients responded poorly to pimozide and had still symptoms at the follow-up. The study indicates, that a large proportion of patients with monosymptomatic delusions of infestation treated with pimozide will be able to discontinue the medication for years without recurrence of their delusions.
Insights
Many patients with delusions of infestation can stop pimozide treatment long-term. Follow-up showed a significant proportion remained symptom-free after discontinuing this delusional disorder medication.
Area of Science:
- Psychiatry
- Neurology
- Pharmacology
Background:
- Monosymptomatic delusions of infestation (MDI) are characterized by a fixed, false belief of being infested with parasites.
- Pimozide is an antipsychotic medication often used to treat MDI.
Purpose of the Study:
- To evaluate the long-term remission rates in patients with MDI after terminating pimozide treatment.
- To assess the recurrence of symptoms and the need for continued medication.
Main Methods:
- Follow-up study of 14 patients diagnosed with MDI.
- Patients were observed for 19-48 months after stopping pimozide.
- Treatment outcomes, including remission and relapse, were recorded.
Main Results:
- Seven out of 14 patients (50%) remained in remission.
- Three patients experienced relapses but managed symptoms with intermittent treatment.
- Four patients showed a poor response to pimozide and had persistent symptoms.
Conclusions:
- A substantial number of MDI patients can achieve long-term remission after discontinuing pimozide.
- Intermittent treatment may be effective for managing relapses.
- Further research into long-term treatment strategies for MDI is warranted.