Influence of age and gender on complexity measures for short term heart rate variability analysis in healthy subjects

Short-term heart rate variability (HRV) analyses (less than 30 min) are suitable for ambulatory care and patient monitoring and can provide an almost immediate test result. Short-term 5 min HRV indices from nonlinear dynamics were determined from 782 females and 1124 males from the KORA S4 database. We applied various fractal and complexity measures with focus on entropies and investigated the influence of age in terms of five age decades (25-34, 35-44, 45-54, 55-64 and 65-74 years) and gender on these HRV indices. The analyses revealed significant modifications of the indices especially by age but partly also by gender especially in the younger groups. These results should be considered in future studies applying nonlinear dynamics, especially if major age and gender differences between the investigated groups are expected.