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Related Experiment Video

Updated: May 7, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
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Published on: December 5, 2025

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Emergency Life Support System aiming preprimed oxygenator.

Takashi Isoyama, Koki Ariyoshi, Kyosuke Nii

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 11, 2013
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    Summary

    A new Troidal Convolution Pump (TCP) for percutaneous cardio-pulmonary support was developed. A novel surface coating using a copolymer reduced protein adsorption on silicone membranes, enhancing biocompatibility for medical devices.

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    Area of Science:

    • Biomedical Engineering
    • Materials Science

    Background:

    • Percutaneous Cardio-Pulmonary Support (PCPS) systems require advanced blood pumps and biocompatible materials.
    • Silicone membranes in medical devices are prone to protein adsorption, potentially leading to complications.

    Purpose of the Study:

    • To develop a novel blood pump for next-generation PCPS systems.
    • To create a new surface coating for silicone hollow fibers to reduce protein adsorption.

    Main Methods:

    • Development of the Troidal Convolution Pump (TCP), a cascade pump design.
    • Creation and application of a novel copolymer coating (PMMSi30) comprising 2-Methacryloyloxyethyl phosphorylcholine (MPC) and a hydrophobic unit (MPTSSi) onto silicone surfaces via physical adsorption.

    Main Results:

    • The Troidal Convolution Pump (TCP) achieved a perfusion of 5 L/min and 350 mmHg at 2450 rpm.
    • The PMMSi30 copolymer, with 30% MPC units, demonstrated optimal molecular design for silicone surfaces.
    • The PMMSi30 coated surface exhibited significantly reduced protein adsorption, adsorbing only 7.2% of the protein adsorbed by a non-coated surface.

    Conclusions:

    • The developed Troidal Convolution Pump (TCP) meets performance requirements for advanced PCPS systems.
    • The novel PMMSi30 copolymer coating effectively reduces protein adsorption on silicone membranes, indicating improved biocompatibility.
    • This surface modification technology holds promise for enhancing the safety and efficacy of blood-contacting medical devices.