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Related Experiment Video

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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
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Resting state inter and intra hemispheric human brain functional connectivity.

Qolamreza R Razlighi, Jason Steffener, Christian Habeck

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 11, 2013
    PubMed
    Summary

    Averaging brain hemisphere signals in fMRI resting-state functional connectivity studies can introduce artifacts. This method is only valid if there are no inter-hemispheric correlations.

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    Area of Science:

    • Neuroimaging
    • Cognitive Neuroscience
    • Brain Connectivity

    Background:

    • Resting-state functional connectivity (RSFC) analysis is a key neuroimaging technique.
    • A common preprocessing step involves averaging signals from homologous brain regions in both hemispheres.
    • This averaging may introduce unintended biases into RSFC findings.

    Purpose of the Study:

    • To mathematically investigate the impact of inter-hemispheric averaging on RSFC.
    • To determine the conditions under which averaging homologous regions is appropriate.

    Main Methods:

    • Mathematical derivation of functional connectivity measures.
    • Analysis of real-world fMRI data from 25 healthy participants.
    • Monte Carlo simulations using null data.

    Main Results:

    • Inter-hemispheric averaging introduces dependency on inter-hemispheric connectivity measures.
    • Averaging can create correlation artifacts in the functional connectivity map.
    • Averaging does not alter resting-state brain connectivity maps if no inter-hemispheric correlations exist.

    Conclusions:

    • Inter-hemispheric averaging in fMRI RSFC analysis is not always appropriate.
    • Researchers should carefully consider the potential for introduced artifacts.
    • The validity of averaging depends critically on the absence of inter-hemispheric correlations.