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Related Experiment Video

Updated: May 7, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

13.0K

Histological observation for needle-tissue interactions.

Yoshiyuki Nakagawa, Yoshihiko Koseki

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 11, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Needle insertion into tissue causes fractures and deformations. Blade orientation relative to muscle fibers significantly impacts fracture type and insertion force, affecting medical procedures.

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    Area of Science:

    • Histology
    • Biomechanical Engineering
    • Medical Device Design

    Background:

    • Understanding tissue response to needle insertion is crucial for medical procedures.
    • Minimally invasive techniques require precise control and predictable tissue interaction.
    • Current knowledge on needle-induced tissue damage, particularly fracture patterns, is limited.

    Purpose of the Study:

    • To investigate histological changes in tissue following ex vivo needle insertion.
    • To analyze the relationship between needle blade orientation and resulting tissue fractures and deformations.
    • To correlate these findings with needle insertion resistance forces.

    Main Methods:

    • Formalin-fixed tissue samples with needles retained in situ.
    • Microtomy, staining, and microscopic observation of needle insertion sites.
    • Novel histological method preserving needle-induced deformations for analysis.

    Main Results:

    • Needle insertion causes distinct tissue fractures and deformations.
    • Perpendicular needle blade orientation resulted in transfiber fractures and large longitudinal deformations.
    • Parallel needle blade orientation led to interfiber fractures and smaller longitudinal deformations.

    Conclusions:

    • Needle blade orientation relative to muscle fibers is a critical factor in tissue damage.
    • Understanding these fracture mechanics can inform the design of needles and improve insertion techniques.
    • This histological approach provides valuable insights into needle-tissue interactions.