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Blastogenesis-suppressing serum factors, decreased immunoglobulin A, and increased beta 1-globulins in Airedale
In Airedale Terriers with diskospondylitis, immunologic tests revealed heat-stable blastogenesis-suppressing serum factors affecting primarily the effector (phytohemagglutinin-sensitive) lymphocytes; decreased serum concentrations of immunoglobulin A; and increased serum concentrations of undetermined beta 1-globulins. Data indicated that the dogs had decreased immunoglobulin A production and were immunosuppressed, which probably contributed to penetration of bacteria into the body and subsequent spreading to the disks. Eosinophilia and basophilia were also detected, which indicated a potential for a type-I hypersensitivity reaction that may have ameliorated the inflammatory reaction.
In Airedale Terriers with diskospondylitis, immunologic tests revealed heat-stable blastogenesis-suppressing serum factors affecting primarily the effector (phytohemagglutinin-sensitive) lymphocytes; decreased serum concentrations of immunoglobulin A; and increased serum concentrations of undetermined beta 1-globulins. Data indicated that the dogs had decreased immunoglobulin A production and were immunosuppressed, which probably contributed to penetration of bacteria into the body and subsequent spreading to the disks. Eosinophilia and basophilia were also detected, which indicated a potential for a type-I hypersensitivity reaction that may have ameliorated the inflammatory reaction.