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Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Infectious Diseases

Background:

  • Tuberculosis (TB) treatment relies on drugs over 40 years old.
  • Emerging drug-resistant Mycobacterium tuberculosis strains and HIV co-infection pose global health challenges.
  • There is an urgent need for novel anti-TB drug candidates.

Purpose of the Study:

  • To review the significance of fluorinated molecules in combating tuberculosis.
  • To highlight current and developing fluorinated compounds for TB treatment.
  • To identify potential future therapeutic alternatives for tuberculosis.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of fluorinated compounds in clinical and pre-clinical development.
  • Identification of promising prototype drug candidates.

Main Results:

  • Fluorine incorporation significantly impacts the biological activity of medicinal compounds.
  • Several fluorinated molecules are in advanced stages of development for TB treatment.
  • Emerging prototypes show promise for future tuberculosis therapy.

Conclusions:

  • Fluorinated molecules represent a vital strategy in the development of new tuberculosis drugs.
  • Continued research into fluorinated compounds is essential for addressing the challenge of drug-resistant TB.
  • These compounds offer a promising avenue for future tuberculosis treatment regimens.