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Fetomaternal outcome with hepatitis e in pregnancy.
Tahira Yasmeen1, Haleema A Hashmi, Aisha Taj
1Department of Obstetrics and Gynaecology, Liaquat National Hospital, Karachi.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|October 12, 2013
Summary
Hepatitis E infection in pregnancy leads to severe maternal complications and high mortality, particularly in the third trimester. This study highlights the critical need for vigilance and management of HEV during pregnancy.
Area of Science:
- Hepatology
- Infectious Diseases
- Maternal-Fetal Medicine
Background:
- Hepatitis E virus (HEV) infection poses significant risks during pregnancy.
- Understanding HEV's impact on maternal and fetal health is crucial for clinical management.
Purpose of the Study:
- To evaluate maternal morbidity and mortality associated with Hepatitis E virus infection in pregnant women.
- To assess the fetal outcomes in pregnancies complicated by HEV.
Main Methods:
- A cross-sectional study was conducted at Liaquat National Hospital, Karachi, from May 2008 to April 2010.
- Thirty pregnant patients with serologically confirmed HEV infection were included.
- Maternal health, including liver function tests and coagulation profiles, and fetal outcomes were monitored.
Main Results:
- Maternal morbidities were most pronounced in the third trimester, with significant clinical and laboratory derangements.
- A maternal mortality rate of 29.3% (8 out of 30 patients) was observed.
- The perinatal mortality rate was 30.3 per 1000 live births.
Conclusions:
- Hepatitis E infection follows a severe course in pregnancy.
- Mortality rates are notably high, especially during the third trimester and postpartum period.
- Prompt diagnosis and management are essential for improving outcomes in HEV-infected pregnant individuals.
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