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Estimating reliable paediatric reference intervals in clinical chemistry and haematology

Peter Ridefelt1, Dan Hellberg, Mattias Aldrimer

  • 1Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|October 12, 2013
PubMed

Insights

Establishing reliable paediatric reference intervals is crucial for accurate clinical chemistry and haematology. Recent studies from Sweden, Denmark, and Canada have significantly advanced this field for healthy children.

Area of Science:

  • Clinical Chemistry
  • Paediatric Haematology
  • Reference Interval Studies

Background:

  • High-quality studies on paediatric reference intervals for clinical chemistry and haematology are scarce.
  • Accurate reference intervals are essential for diagnosing and monitoring diseases in children.

Purpose of the Study:

  • To review and summarize current reference interval studies for common clinical chemistry and haematology analyses in paediatric populations.
  • To highlight recent advancements in establishing paediatric reference intervals.

Main Methods:

  • Review of prospective, community-based projects.
  • Utilisation of blood samples from healthy children in Sweden, Denmark, and Canada.

Main Results:

  • Three recent studies have substantially improved the availability of high-quality paediatric reference intervals.
  • Data covers general clinical chemistry and haematology analytes.

Conclusions:

  • The reviewed studies provide a more robust foundation for paediatric reference intervals.
  • Further research may build upon these findings to refine diagnostic criteria for children.
Abstract

Keywords:
ChildrenClinical chemistryHaematologyPaediatricReference interval

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