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Updated: May 7, 2026
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Peritumoral deposits as an adverse prognostic indicator of colorectal cancer
Hideki Ueno1, Yojiro Hashiguchi2, Hideyuki Shimazaki3
1Department of Surgery, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan.
Background:
The aim of this study was to determine the prognostic value of peritumoral deposits (PTDs) in colorectal cancer (CRC).
Methods:
A total of 695 patients with pT3/T4 CRC (1980 to 1999) were reviewed. Tumor deposits located ≥2 mm from the front of the direct spread in the primary tumor were evaluated as PTDs.
Results:
PTDs were observed in 111 patients (16.0%). The incidence of PTDs increased according to increasing N stage: 7% for N0, 22% for N1, and 39% for N2 (P < .0001). Five-year disease-specific survival was 85.0% in patients without PTDs and 59.5% in those with PTDs (P < .0001). Multivariate analysis showed that PTDs affected disease-specific survival independent of T and N stages. A significant prognostic impact of PTDs was similarly observed in another cohort comprising 474 patients with pT3/T4 CRC (2000 to 2005). The κ values among 8 observers were .70 for PTDs and .32 for the conventional growth pattern.
Conclusions:
PTDs have considerable prognostic relevance and offer improved judgment reproducibility in assessing the invasive margin of CRC.
