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Published on: October 24, 2025
The changing prevalence of infertility
Felice Petraglia1, Gamal I Serour, Charles Chapron
1Department of Molecular and Developmental Medicine, Obstetrics and Gynecology, University of Siena, Policlinico "Le Scotte", Siena, Italy.
Infertility is a growing global concern, influenced by lifestyle, infections, and delayed childbearing. Treatments for cancer can also impact fertility, highlighting the need for fertility preservation methods.
Area of Science:
- Reproductive Health
- Global Health Epidemiology
Background:
- Infertility prevalence is rising globally, affecting both high- and low-income nations.
- Key contributing factors include lifestyle, nutrition, infections, and sexually transmitted diseases.
- Delayed childbearing increases risks for sexually transmitted diseases and gynecological conditions like endometriosis and polycystic ovary syndrome.
Purpose of the Study:
- To explore the multifaceted causes of increasing infertility worldwide.
- To identify lifestyle, environmental, and medical factors contributing to fertility decline.
- To underscore the importance of fertility preservation, particularly post-oncologic treatment.
Main Methods:
- This abstract is based on a review of current literature and epidemiological data on infertility.
- It synthesizes information on various etiological factors impacting reproductive health.
- No specific experimental methods are detailed; it's a conceptual overview.
Main Results:
- Increasing infertility is linked to delayed childbearing, increased risk of STDs, and conditions like fibroids, endometriosis, PCOS, and anovulation.
- Chronic stress and environmental pollutants are identified as significant contributors to reduced fertility.
- Cancer survivors face fertility loss due to gonadotoxic oncologic treatments.
Conclusions:
- The rising incidence of infertility necessitates a comprehensive understanding of its diverse causes.
- Addressing lifestyle, environmental, and medical factors is crucial for reproductive health.
- Developing and implementing fertility preservation strategies is essential for cancer survivors and others at risk.
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