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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Related Experiment Video

Updated: May 7, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Deep brain stimulation: how does it work?

Filippo Agnesi¹, Matthew D Johnson, Jerrold L Vitek

¹Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.

Handbook of Clinical Neurology

|October 12, 2013

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) offers a surgical treatment for movement disorders. Its therapeutic mechanisms involve activating stimulated nuclei, overriding pathological activity, and inducing network changes, varying by stimulation site and disorder.

Keywords:

computer modeling deep brain stimulation electrophysiology high-frequency stimulation imaging mechanism of action neurochemistry neuromodulation

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Related Experiment Videos

Last Updated: May 7, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Deep Brain Stimulation with Simultaneous fMRI in Rodents

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Published on: February 15, 2014

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Published on: January 6, 2011

Area of Science:

Neuroscience
Neurological Surgery

Background:

Deep brain stimulation (DBS) is an established treatment for refractory movement disorders.
Understanding DBS mechanisms is crucial for improving efficacy and exploring new applications.

Purpose of the Study:

To review the current understanding of the therapeutic mechanisms of DBS.
To explore how DBS affects neuronal activity and network function.

Main Methods:

Review of electrophysiological experiments.
Analysis of biochemical data.
Examination of computer modeling and imaging studies.

Main Results:

DBS paradoxically activates the output of stimulated nuclei, rather than inhibiting them.
This activation overrides pathological neural activity and promotes synaptic plasticity.
Therapeutic effects depend on stimulation site and the specific neurological disorder.

Conclusions:

The precise mechanisms of DBS are complex and multifactorial.
Site-specific and disorder-specific adaptations are key to DBS efficacy.
Further research is needed to fully elucidate and optimize DBS therapies.