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Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
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Central motor conduction time.

Kaviraja Udupa1, Robert Chen

  • 1Division of Neurology, Department of Medicine, University of Toronto and Division of Brain Imaging & Behaviour Systems - Neuroscience, Toronto Western Research Institute, Toronto, Canada.

Handbook of Clinical Neurology
|October 12, 2013
PubMed
Summary
This summary is machine-generated.

Central motor conduction time (CMCT) measures neural impulse travel through the central nervous system. Prolonged CMCT indicates neurological conditions like multiple sclerosis and aids in diagnosis and prognosis.

Keywords:
central motor conduction time (CMCT)diagnostic utilities of TMSmovement disorderstranscranial magnetic stimulation (TMS)

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Area of Science:

  • Neuroscience
  • Clinical Electrophysiology

Background:

  • Central motor conduction time (CMCT) quantifies neural impulse transit through the central nervous system.
  • CMCT development in children reaches adult levels around age six for lower limbs.
  • Alterations in CMCT are indicative of various neurological disorders.

Purpose of the Study:

  • To review the alterations of Central motor conduction time (CMCT) in various neurological conditions.
  • To highlight the diagnostic and prognostic value of CMCT in specific neurological disorders.

Main Methods:

  • Calculation of CMCT involves transcranial magnetic stimulation (TMS) of the motor cortex.
  • CMCT is determined by subtracting peripheral conduction time from motor evoked potential latency.
  • Review of existing literature on CMCT alterations in neurological diseases.

Main Results:

  • Prolongation of CMCT signifies slowed conduction in corticospinal fibers, observed in demyelinating diseases (e.g., multiple sclerosis), structural lesions (stroke, myelopathy), and neurodegenerative disorders.
  • Elevated CMCT is noted in conditions such as multiple sclerosis, amyotrophic lateral sclerosis, and myelopathy.
  • CMCT demonstrates diagnostic utility when combined with other clinical and electrophysiological assessments.

Conclusions:

  • Prolonged CMCT is a key indicator in diagnosing neurological conditions like myelopathy, amyotrophic lateral sclerosis, and multiple sclerosis.
  • CMCT serves as a valuable prognostic marker for conditions including myelopathy and multiple sclerosis.
  • Understanding CMCT alterations is crucial for the clinical evaluation of corticospinal tract integrity.