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Tourette syndrome.

Nasrin Shahana1, Donald L Gilbert

  • 1Department of Neuroscience, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Handbook of Clinical Neurology
|October 12, 2013
PubMed
Summary
This summary is machine-generated.

Transcranial magnetic stimulation (TMS) research reveals potential abnormalities in brain pathways for Tourette syndrome (TS). These findings may explain tics and co-occurring conditions like ADHD and OCD.

Keywords:
Tourette syndromeattention-deficit/hyperactivity disorder (ADHD)child nervous systemmotor cortexmotor evoked potential (MEP)neuroplasticityshort-interval cortical inhibition (SICI)

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Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Tourette syndrome (TS) is a neurological disorder with motor and vocal tics, often co-occurring with ADHD and OCD.
  • Understanding the neurobiological underpinnings of TS is crucial for developing effective treatments.

Purpose of the Study:

  • To critically review research applications of transcranial magnetic stimulation (TMS) in Tourette syndrome.
  • To analyze findings from TMS studies investigating motor cortex function in TS.
  • To explore the implications of TMS research for understanding TS pathophysiology.

Main Methods:

  • Synopsis of case-control studies using single- and paired-pulse TMS techniques.
  • Analysis of newer theta-burst stimulation applications.
  • Examination of TMS measurements applied to the resting motor cortex.

Main Results:

  • Intriguing findings suggest abnormalities in inhibitory or modulatory pathways in TS.
  • TMS techniques reveal potential disruptions underlying tic manifestation.
  • Evidence points to altered neural pathways possibly contributing to co-occurring ADHD and OCD.

Conclusions:

  • TMS research offers valuable insights into the neurobiology of Tourette syndrome.
  • Abnormalities in neural pathways identified through TMS may explain core TS symptoms and comorbidities.
  • Future TMS applications hold promise for advancing TS research and understanding.