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Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
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Raynaud's phenomenon (primary).

Janet Pope1

  • 1St Joseph's Health Care Rheumatology Centre, London, Ontario, Canada.

BMJ Clinical Evidence
|October 12, 2013
PubMed
Summary

This review examines drug treatments for primary Raynaud's phenomenon, a condition causing episodic vasospasm. It found evidence on the effectiveness and safety of calcium channel blockers like amlodipine and nifedipine.

Area of Science:

  • Vascular Medicine
  • Pharmacology

Background:

  • Raynaud's phenomenon involves episodic, reversible vasospasm of peripheral arteries, typically in the digits.
  • Primary Raynaud's phenomenon occurs without an underlying disease and its prevalence varies geographically and by occupational exposure.
  • Symptoms include color changes (pallor, cyanosis, redness), pain, and potentially digital ulceration.

Purpose of the Study:

  • To systematically review the effects of drug treatments for primary Raynaud's phenomenon.
  • To evaluate the effectiveness and safety of various pharmacological interventions.

Main Methods:

  • A systematic review was conducted, searching major medical databases up to August 2013.
  • Included studies comprised systematic reviews, randomized controlled trials (RCTs), and observational studies.

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  • GRADE methodology was used to assess the quality of evidence for interventions.

    • Main Results:

    • Nine studies met the inclusion criteria for the review.
    • The review identified and evaluated evidence for specific drug treatments.

    Conclusions:

    • The systematic review presents findings on the effectiveness and safety of amlodipine, diltiazem, nicardipine, and nifedipine.
    • These calcium channel blockers are key interventions discussed for primary Raynaud's phenomenon.