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Updated: May 7, 2026

Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations

Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations

Published on: November 7, 2019

Ubiquitin: molecular modeling and simulations.

Assaf Ganoth¹, Yossi Tsfadia, Reuven Wiener

¹The Interdisciplinary Center (IDC), P.O. Box 167, Herzliya 46150, Israel; Department of Biology and Environment, The Faculty of Natural Sciences, University of Haifa - Oranim, Tivon 36006, Israel.

Journal of Molecular Graphics & Modelling

|October 12, 2013

Summary

Ubiquitin tagging targets proteins for destruction and regulates vital cellular functions. Molecular modeling and simulations offer dynamic insights into the ubiquitin system, crucial for understanding diseases.

Keywords:

AFM Computer simulations DUB MD Molecular dynamics Molecular modeling PTM RDC UBC Ub Ub-conjugating domain Ubiquitin atomic force microscopy deubiquitinating enzyme molecular dynamics post-translational modification residual dipolar coupling ubiquitin

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Last Updated: May 7, 2026

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Published on: November 7, 2019

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Published on: May 14, 2021

Area of Science:

Biochemistry
Molecular Biology
Computational Biology

Background:

Protein homeostasis is maintained through synthesis and degradation.
Ubiquitin tagging, discovered in the 1970s, is key to protein degradation and cellular functions.
Dysfunctions in the ubiquitin system are linked to cancer, neurodegenerative, and immunological disorders.

Purpose of the Study:

To provide an overview of molecular modeling and simulations of ubiquitin.
To evaluate the current status of computational research on the ubiquitin system.
To offer perspectives on future advancements in this field.

Main Methods:

Review of existing literature on ubiquitin and computational methodologies.
Analysis of molecular modeling and molecular dynamics simulation applications.
Evaluation of the role of computational approaches in understanding protein dynamics.

Main Results:

Ubiquitin tagging is essential for protein degradation and diverse cellular processes.
Computational methods, particularly molecular modeling and dynamics, are increasingly vital.
These methods bridge the gap between protein structure and function, providing dynamic insights.

Conclusions:

Deciphering the ubiquitin system's complexity is critical for understanding various diseases.
Molecular modeling and simulations are powerful tools for elucidating ubiquitin system dynamics.
Continued computational research will advance our understanding and therapeutic strategies for ubiquitin-related disorders.