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Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
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Lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program.

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The U.S. Endocrine Disruptor Screening Program (EDSP) evaluated pesticides for endocrine disruption effects. A recent workshop gathered experts to review lessons learned and recommend future directions for this critical environmental health program.

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Area of Science:

  • Environmental Chemistry
  • Toxicology
  • Regulatory Science

Background:

  • The U.S. Congress mandated endocrine pathway screening for pesticides and contaminants via the Food Quality Protection Act and Safe Drinking Water Act.
  • The U.S. Environmental Protection Agency (EPA) established the Endocrine Disruptor Screening Program (EDSP) to address these requirements.
  • EDSP focuses on developing and validating assays for estrogen, androgen, and thyroid (EAT) pathways.

Purpose of the Study:

  • To review the performance and practical applications of EDSP Tier 1 screening assays.
  • To gather insights from stakeholders on challenges and opportunities in endocrine disruptor testing.
  • To inform future directions and improvements for the EDSP evaluations.

Main Methods:

  • A workshop convened over 240 scientists from diverse sectors (government, industry, academia, non-profit).
  • Discussions were organized into three sessions: Assay Performance, Data Application, and Future Testing.
  • Retrospective analysis of data generated from EDSP Tier 1 assays was a key focus.

Main Results:

  • Over 50 pesticide actives and 2 inert ingredients have been evaluated using EDSP Tier 1 assays (in vitro and in vivo).
  • Key learnings and recommendations regarding the performance and application of EDSP Tier 1 assays were identified.
  • The workshop highlighted practical applications of Tier 1 data and opportunities for future endocrine testing.

Conclusions:

  • The EDSP has made progress in screening chemicals for endocrine disruption potential.
  • Stakeholder collaboration is crucial for refining and advancing endocrine disruptor screening methodologies.
  • Recommendations from the workshop will guide the future evolution of the EDSP.