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Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
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HER2 expression in carcinomas of the true cardia (Siewert type II esophagogastric junction carcinoma)

Hitoshi Katai1, Michihiro Ishida, Hiroharu Yamashita

  • 1Gastric Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan, hkatai@ncc.go.jp.

World Journal of Surgery
|October 12, 2013
PubMed
Abstract

Insights

HER2 positivity predicts liver recurrence in Siewert type II esophagogastric junction carcinoma. Trastuzumab may help prevent hepatic recurrence in patients with HER2-overexpressing tumors.

Area of Science:

  • Oncology
  • Gastroenterology
  • Molecular Diagnostics

Background:

  • Trastuzumab is approved for HER2-positive unresectable metastatic gastric or esophagogastric junction (EGJ) carcinoma.
  • Limited data exists on HER2 status implications in Siewert type II EGJ carcinoma.

Purpose of the Study:

  • To evaluate HER2 status in Siewert type II EGJ carcinoma.
  • To determine the association between HER2 positivity and patient outcomes.
  • To identify HER2 positivity as a predictive factor for liver recurrence.

Main Methods:

  • Retrospective analysis of 208 patients with Siewert type II tumors.
  • Evaluation of HER2 positivity frequency.
  • Examination of correlations between HER2 expression, clinicopathologic features, and outcomes.

Main Results:

  • 18.2% of patients had HER2-positive tumors, associated with differentiated carcinomas.
  • No significant difference in 5-year overall survival between HER2-negative (61.2%) and HER2-positive (48.5%) groups.
  • HER2 positivity was an independent predictor of liver recurrence (p=0.0155), with 23.7% recurrence in the HER2-positive group vs. 7.6% in the HER2-negative group.

Conclusions:

  • HER2 positivity is a strong predictor of liver recurrence in Siewert type II EGJ carcinoma.
  • Adjuvant trastuzumab combined with chemotherapy may prevent hepatic recurrence in resectable EGJ adenocarcinoma with HER2 overexpression.

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