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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
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Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
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Updated: May 7, 2026

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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Mediterranean dietary pattern and chronic diseases.

Salvatore Panico1, Amalia Mattiello, Camilla Panico

  • 1Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy, spanico@unina.it.

Cancer Treatment and Research
|October 12, 2013
PubMed
Summary

The Mediterranean diet, a cornerstone of nutritional epidemiology, consistently protects against cardiovascular diseases and cancers. Even with modern lifestyle changes, adherence to this eating pattern offers significant health benefits.

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Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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Area of Science:

  • Nutritional Epidemiology
  • Chronic Disease Prevention
  • Public Health Nutrition

Background:

  • The Mediterranean diet's protective effects against chronic diseases have been studied since the 1950s.
  • Research, including the Seven Countries Study and European EPIC collaboration, consistently links Mediterranean dietary habits to reduced risk of cardiovascular disease and cancer.
  • Despite globalization leading to less healthy lifestyles, populations maintaining Mediterranean dietary patterns show significant protection.

Purpose of the Study:

  • To review the long-standing evidence on the Mediterranean diet's role in preventing chronic diseases.
  • To highlight the consistency of findings across decades and diverse populations.
  • To emphasize the public health implications of promoting Mediterranean dietary patterns.

Main Methods:

  • Analysis of dietary components, nutrients, and food groups characteristic of the Mediterranean diet.
  • Longitudinal studies and epidemiological research, including the Seven Countries Study and the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
  • Meta-analyses and dietary intervention trials evaluating metabolic risk factors and disease incidence.

Main Results:

  • Consistent evidence demonstrates the Mediterranean diet's protective effect against cardiovascular diseases and various cancers.
  • Recent Italian EPIC cohort data (approx. 50,000 individuals) confirm these protective effects, aligning with European and North American findings.
  • Dietary trials indicate that Mediterranean-style eating improves metabolic risk profiles and reduces the occurrence of chronic diseases.

Conclusions:

  • The Mediterranean diet is a well-evidenced, palatable eating pattern that significantly protects against the epidemic of chronic diseases.
  • Adherence to Mediterranean dietary principles remains a valuable strategy for disease prevention, even amidst changing global lifestyles.
  • Promoting Mediterranean dietary patterns offers a sustainable approach to public health and chronic disease management.