Related Experiment Video
Updated: May 7, 2026

05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
945
Itchy lesions in pigmented skin
Rachel Hung1, Mahreen Ahmeen, Ann Fleming
1King's College London/King's Health Partners, London, Tower Hamlets, UK.
BMJ Case Reports
|October 12, 2013
Summary
Disseminated superficial actinic porokeratosis, a rare skin condition, was diagnosed in a woman with type VI skin. This case highlights its unusual presentation in deeply pigmented skin, a finding rarely documented in medical literature.
Area of Science:
- Dermatology
- Dermatopathology
- Pigmented Skin Conditions
Background:
- Porokeratosis is a rare keratinization disorder.
- Actinic porokeratosis typically affects sun-exposed areas.
- It is infrequently reported in individuals with darker skin types.
Observation:
- A 37-year-old woman with type VI skin presented with a year-long history of itchy, annular, raised-border lesions on her arms, chest, and legs.
- Skin biopsy confirmed disseminated superficial actinic porokeratosis.
Findings:
- The diagnosis of disseminated superficial actinic porokeratosis in a patient with type VI skin is a rare clinical occurrence.
- This presentation is unusual given the typical demographic and skin types affected by this condition.
Implications:
- This case underscores the importance of considering porokeratosis in the differential diagnosis of pruritic lesions in patients with pigmented skin.
- Further research is needed to understand the specific factors contributing to porokeratosis development in darker skin types.
- Increased awareness may improve early diagnosis and management of this rare condition in diverse populations.
Related Concept Videos
Pigmentation
3.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
3.8K
Skin Diseases and Disorders
5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K
Skin Cancer
5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
Changes in Skin Color: Clinical Perspectives
3.6K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.6K
Pleiotropy
31.3K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
31.3K
Endocarditis II: Clinical Features of Infective Endocarditis
953
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
953

