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High hsCRP is associated with reduced lung function in structural firefighters.

Denise M Gaughan1, David C Christiani, Michael D Hughes

  • 1Department of Preventive Medicine, Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts.

American Journal of Industrial Medicine
|October 12, 2013
PubMed
Summary

Systemic inflammation, measured by high-sensitivity C-reactive protein (hsCRP), is linked to reduced lung function in structural firefighters. Higher hsCRP levels correlate with decreased forced expiratory volume and vital capacity.

Keywords:
high-sensitivity C-reactive protein (hsCRP)percent predicted forced expiratory volume in 1 s (FEV1%-predicted)percent predicted forced vital capacity (FVC%-predicted)

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Area of Science:

  • Occupational Health
  • Pulmonary Medicine
  • Inflammation Research

Background:

  • Structural firefighters face occupational exposures potentially leading to systemic inflammation.
  • Systemic inflammation is increasingly recognized as a factor influencing various organ systems, including the lungs.

Purpose of the Study:

  • To investigate the association between systemic inflammation markers and pulmonary function in structural firefighters.
  • To determine if high-sensitivity C-reactive protein (hsCRP) can serve as an indicator of lung function impairment in this population.

Main Methods:

  • A cohort of 401 male career firefighters from a Midwestern fire department was studied.
  • Data collection included questionnaires, spirometry for lung function assessment (FEV1 %-predicted and FVC%-predicted), and measurement of hsCRP as a systemic inflammation biomarker.

Main Results:

  • Elevated hsCRP levels were significantly associated with lower lung function.
  • A twofold increase in log10-hsCRP corresponded to a mean decrease of 1.5% in FEV1 %-predicted and 1.4% in FVC%-predicted, after adjusting for confounders.

Conclusions:

  • High-sensitivity C-reactive protein (hsCRP) may serve as a valuable biomarker for detecting reduced lung function in structural firefighters.
  • Findings suggest a link between systemic inflammation and occupational lung disease risk in firefighters.