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Updated: May 7, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis
Published on: January 7, 2019
Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3
Stefanie Neubauer1, Florian Rechenmacher, Ambros J Beer
1Institute for Advanced Study at the Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching (Germany) http://www.org.chemie.tu-muenchen.de.
Abstract:
Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.

