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Updated: May 7, 2026

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
Association between Mannose-binding lectin gene polymorphisms and hepatitis B virus infection: a meta-analysis
Hang-di Xu1, Ming-fei Zhao, Tian-hong Wan
1Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Mannose-binding lectin gene (mbl2) exon1 polymorphisms do not appear to influence chronic hepatitis B (CHB) risk. However, specific mbl2 genotypes are linked to severe hepatitis B (SHB) and liver cirrhosis (LC) progression.
Area of Science:
- Immunogenetics
- Hepatology
- Molecular Biology
Background:
- Conflicting study results exist regarding the association between Mannose-binding lectin gene (mbl2) polymorphisms and Hepatitis B Virus (HBV) infection.
- Clarifying the role of mbl2 gene variations in chronic hepatitis B (CHB) susceptibility and progression is crucial.
Purpose of the Study:
- To conduct a meta-analysis to resolve inconsistencies in previous research.
- To investigate the association between mbl2 polymorphisms and the chronicity or progression of HBV infection.
Main Methods:
- A systematic literature search was performed on PubMed and Embase.
- A meta-analysis was conducted using Odds Ratios (OR) and 95% Confidence Intervals (CI).
- Included studies comprised healthy controls, spontaneous recovered patients, CHB cases, and progressive hepatitis B cases.
Main Results:
- No significant association was found between mbl2 exon1 polymorphisms and CHB risk compared to healthy or recovered groups.
- Stratified analysis by ethnicity also revealed no clear link between mbl2 polymorphism and CHB risk.
- A significant association was observed between the mbl2 AO/OO genotype and severe hepatitis B (SHB) or liver cirrhosis (LC) (OR=3.66-3.88).
- No association was found between the mbl2 AO/OO genotype and hepatocellular carcinoma (HCC).
Conclusions:
- mbl2 exon1 polymorphisms are unlikely to be significantly associated with HBV infection chronicity.
- mbl2 polymorphisms, particularly the AO/OO genotype, may be significantly related to the progression of HBV to severe forms like SHB and LC.
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