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Circulating adipocytokines and chronic kidney disease
Katherine T Mills1, L Lee Hamm, A Brent Alper
1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
Plos One
|October 12, 2013
Summary
Adipokines like leptin and resistin are linked to chronic kidney disease (CKD) risk and severity. Higher levels of these adipokines and adiponectin are independently associated with reduced kidney function and increased albuminuria in CKD patients.
Area of Science:
- Endocrinology
- Nephrology
- Cardiovascular Disease
Background:
- Adipokines are implicated in atherosclerotic heart disease, sharing risk factors with chronic kidney disease (CKD).
- The specific relationship between key adipokines and CKD requires further characterization.
Purpose of the Study:
- To investigate the association of plasma leptin, resistin, and adiponectin with the presence and severity of CKD.
- To determine if these adipokines are independent predictors of CKD.
Main Methods:
- Cross-sectional study involving 201 CKD patients and 201 controls.
- CKD defined by estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² or albuminuria.
- Quantile and logistic regression models adjusted for multiple confounding factors were employed.
Main Results:
- Significantly higher plasma leptin and resistin levels were observed in CKD cases compared to controls.
- Elevated leptin and resistin were independently associated with increased CKD odds.
- Higher adiponectin also showed a significant association with increased CKD odds.
- All three adipokines were independently linked to lower eGFR and higher urinary albumin levels.
Conclusions:
- Adipocytokines (leptin, resistin, adiponectin) are significantly and independently associated with CKD risk and severity.
- Further longitudinal studies are recommended to explore the prospective role of adipocytokines in CKD development and progression.
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