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Updated: May 7, 2026

A High-throughput Assay for the Prediction of Chemical Toxicity by Automated Phenotypic Profiling of Caenorhabditis elegans

A High-throughput Assay for the Prediction of Chemical Toxicity by Automated Phenotypic Profiling of Caenorhabditis elegans

Published on: March 14, 2019

Assaying environmental nickel toxicity using model nematodes.

David Rudel¹, Chandler D Douglas, Ian M Huffnagle

¹Department of Biology, East Carolina University, Greenville, North Carolina, United States of America.

|October 12, 2013

Summary

This summary is machine-generated.

Environmental nickel contamination harms nematode survival and longevity, especially when bound to sediment. Aqueous nickel reduces reproduction, highlighting risks to animal health.

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Area of Science:

Environmental toxicology
Ecotoxicology
Nickel toxicity

Background:

Nickel is a common environmental contaminant with known human health risks.
The environmental impact of nickel on animal health is not well understood.
Nickel contaminates waterways, binding to soils and sediments.

Purpose of the Study:

To evaluate the toxic effects of environmental nickel levels on animal health.
To assess the impact of sediment-bound and aqueous nickel on nematode physiology.
To compare the responses of Caenorhabditis elegans and Pristionchus pacificus to nickel exposure.

Main Methods:

Assays conducted on C. elegans and P. pacificus using nickel-spiked sediments and aqueous nickel.
Evaluated effects on growth, developmental survival, lifespan, and fecundity.
Used environmental contaminant levels of nickel (8.9–7,600 µg Ni/g sediment; 50–800 µg NiCl2/L water).

Main Results:

Nickel-spiked sediment significantly impaired nematode survival and longevity in a concentration-dependent manner.
Aqueous nickel did not affect survivorship or longevity but significantly reduced fecundity.
Both nematode species showed similar, though not identical, responses to nickel exposure.

Conclusions:

Sediment-bound nickel poses a substantial risk to nematode health and survival.
Aqueous nickel can negatively impact nematode reproductive capacity.
Environmental toxicological studies could benefit from using a wider range of nematode species, including P. pacificus, which tolerates less hospitable sediments.