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Cyclic peptides as therapeutic agents and biochemical tools
1Laboratory of Biochemistry, College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea.
Biomolecules & Therapeutics
|October 12, 2013
Summary
Cyclic peptides exhibit diverse biological activities and are developed using genetic and synthetic methods. These peptides show promise as therapeutic agents and biochemical tools for various applications.
Area of Science:
- Peptide Chemistry
- Medicinal Chemistry
- Biotechnology
Background:
- Cyclic peptides possess a wide range of biological activities, including antibacterial, immunosuppressive, and anti-tumor properties.
- Natural cyclic peptides inspire the development of novel analogs with therapeutic potential.
Purpose of the Study:
- To review the genetic and synthetic methodologies for cyclic peptide development.
- To highlight the applications of cyclic peptides as therapeutic agents and biochemical tools.
Main Methods:
- Genetic methods: phage display, intein-based cyclization, and mRNA display.
- Synthetic methods: individual, parallel, and split-and-pool synthesis.
- Split-and-pool synthesis enables on-bead, in-solution, and microarray screening of cyclic peptide libraries.
Main Results:
- Development of diverse cyclic peptides with significant biological activities.
- Advancements in screening technologies for identifying active cyclic peptides.
- Established utility of cyclic peptides as receptor modulators, RNA binders, and enzyme inhibitors.
Conclusions:
- Cyclic peptides are versatile molecules with broad therapeutic and research applications.
- Continued innovation in cyclic peptide synthesis and screening will yield new therapeutic agents.
- Cyclic peptides are valuable as both drug candidates and essential biochemical tools.
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