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Development of the Mayo Investigational Neuromodulation Control System: toward a closed-loop electrochemical feedback
Su-Youne Chang1, Christopher J Kimble, Inyong Kim
1Departments of Neurologic Surgery and.
Journal of Neurosurgery
|October 15, 2013
Summary
This study introduces MINCS and WINCS, a novel system for real-time neurochemical recording during deep brain stimulation (DBS). This integrated approach enables artifact-free feedback, paving the way for smarter, closed-loop DBS therapies.
Area of Science:
- Neuroscience
- Biomedical Engineering
Background:
- Conventional deep brain stimulation (DBS) operates on an open-loop system, lacking real-time neural feedback.
- Neurochemical feedback holds potential for improving DBS therapeutic outcomes.
- Fast-scan cyclic voltammetry (FSCV) effectively records neurochemical changes but conflicts with conventional DBS devices.
Purpose of the Study:
- To develop and test an integrated system for simultaneous neurochemical recording and neuromodulation.
- To overcome interference issues between DBS and FSCV.
- To advance the development of closed-loop DBS systems.
Main Methods:
- Developed the Mayo Investigational Neuromodulation Control System (MINCS) for wireless stimulation.
- Integrated MINCS with the Wireless Instantaneous Neurochemical Concentration Sensing System (WINCS) for FSCV.
- Applied varying electrical stimulation frequencies to the rat medial forebrain bundle and recorded striatal dopamine release.
Main Results:
- Achieved artifact-free, wireless FSCV recordings by interleaving stimulation and scanning.
- Demonstrated that MINCS-induced stimulation elicited time-locked striatal dopamine release.
- Observed a progressive increase in dopamine release with increasing stimulation frequency.
Conclusions:
- MINCS is a reliable device for wireless stimulation concurrent with artifact-free neurochemical recording via WINCS.
- This integration represents a significant step toward closed-loop DBS systems.
- The system shows promise for future human applications in neuromodulation.
