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Effect of exercise on plasma interferon levels.

A Viti, M Muscettola, L Paulesu

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |August 1, 1985
    PubMed
    Summary
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    Submaximal exercise significantly boosts plasma interferon activity, specifically the alpha-type. This finding suggests a link between physical exertion and immune system response, without altering key blood markers.

    Area of Science:

    • Immunology
    • Exercise Physiology

    Background:

    • Interferons are crucial cytokines involved in immune responses.
    • The impact of acute exercise on plasma interferon levels remains incompletely understood.

    Purpose of the Study:

    • To investigate the effect of a single bout of submaximal exercise on plasma interferon activity.
    • To characterize the type of interferon affected by exercise.

    Main Methods:

    • Eight healthy males performed 1 hour of cycling exercise at 70% VO2 max.
    • Plasma samples were collected pre- and post-exercise.
    • Interferon activity was measured, and immunological characterization was performed.
    • Plasma protein, lipid, glucose, lactate, hematocrit, and plasma protein were monitored.

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    Main Results:

    • Plasma interferon activity significantly increased post-exercise (from 3 +/- 1 to 7 +/- 2 IU/ml).
    • The elevated interferon was identified as acid-labile and alpha-type.
    • No significant changes were observed in plasma protein, lipid, or glucose.
    • Blood lactate showed a slight increase, and hemoconcentration did not occur.

    Conclusions:

    • A single session of submaximal exercise enhances plasma interferon activity.
    • Exercise-induced increases in interferon are primarily of the alpha-type.
    • These findings highlight a potential immunomodulatory effect of acute exercise.