Related Experiment Video
Updated: May 7, 2026

Cellular Redox Profiling Using High-content Microscopy
Published on: May 14, 2017
Redox pioneer: Professor Joe M. McCord
David M Schnell1, Daret St Clair
11 Graduate Center for Nutritional Sciences, University of Kentucky , Lexington, Kentucky.
Abstract:
Dr. Joe McCord (Ph.D. 1970) is recognized here as a Redox Pioneer because he has published at least three articles on antioxidant/redox biology as first/last author that have been cited over 1000 times and has published at least 37 articles each cited over 100 times. Dr. McCord is known for the monumental discovery of the antioxidant superoxide dismutase (SOD) while a graduate student under fellow redox pioneer Irwin Fridovich and demonstrating its necessity to aerobic life. Beyond this, McCord's career is distinguished for bridging the gap from basic science to clinical relevance by showing the application of SOD and superoxide to human physiology, and characterizing the physiological functions of superoxide in inflammation, immunological chemotaxis, and ischemia-reperfusion injury, among other disease conditions. Work by McCord serves as the foundation upon which our understanding of how superoxide functions in a variety of physiological systems is built and demonstrates how superoxide is essential to aerobic life, yet, if left unchecked by SOD, toxic to a multitude of systems. These discoveries have substantial significance in a wide range of studies with applications in cardiovascular disease, cancer, neurology, and medicine, as well as general health and longevity. Dr. McCord's contributions to free radical biology have been recognized through many prestigious achievement awards, honorary titles, and conferences around the world; each serving as a testament to his status as a redox pioneer.
More Related Videos
06:10Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein
Published on: June 18, 2020
07:31Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy
Published on: August 19, 2021
Related Concept Videos
Redox Reactions
Redox Reactions
Redox Equilibria: Overview
Redox Titration: Other Oxidizing and Reducing Agents
Balancing Redox Equations
Redox Titration: Overview