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Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs
Jae-Kook Cha1, Jung-Seok Lee, Min-Soo Kim
1Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul 120-752, Republic of Korea.
Aim:
The objective of this study was to determine the efficacy of bone morphogenetic protein 2 (BMP-2) in a bovine hydroxyapatite/collagen (BHC) carrier to augment bone formation in a canine nasal sinus model.
Methods:
Eight mongrel dogs, approximately 12 months old and 30 kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with E. coli-derived BMP-2 at 0.1 mg/ml was implanted in four animals, and BHC loaded with E. coli-derived BMP-2 at 0.5 and 1.5 mg/ml was implanted in four animals. The animals were euthanized at 20 weeks when block sections were obtained for micro-computed tomography and histometric analyses.
Results:
Total augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the BMP-2 groups compared with control.
Conclusion:
BMP-2 in a BHC carrier, even at the low 0.1-mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.
