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The relationship between body growth and pulmonary function in children with cystic fibrosis

Janna W Woestenenk1, Rebecca K Stellato, Suzanne W Terheggen-Lagro

  • 1Internal Medicine and Dermatology, Dietetics and, Cystic Fibrosis Centre Utrecht, University Medical Centre Utrecht, Utrecht, The Netherlands.

Acta Paediatrica (Oslo, Norway : 1992)
|October 15, 2013
PubMed

Insights

Children with cystic fibrosis (CF) experience impaired growth. However, weight gain in these patients significantly slowed the decline in lung function, specifically forced expiratory volume in 1 sec (FEV1).

Area of Science:

  • Pediatric Pulmonology
  • Growth and Development in Chronic Illness
  • Cystic Fibrosis Research

Background:

  • Children with cystic fibrosis (CF) often exhibit impaired growth patterns.
  • Monitoring anthropometric measurements is crucial for assessing the health status of pediatric CF patients.

Purpose of the Study:

  • To measure weight and height in children with CF aged 2-10 years.
  • To investigate the relationship between anthropometric parameters and lung function (FEV1) from age 6.

Main Methods:

  • Weight and height were assessed using z-scores: weight-for-age (WFA), height-for-age (HFA), height-adjusted-for-target-height (HFA/TH), and weight-for-height (WFH).
  • Children were categorized based on z-scores at 2 years of age.
  • Cross-sectional and longitudinal analyses examined the association between anthropometric measures and FEV1.

Main Results:

  • Mean weight and height in the 156 enrolled CF children were below healthy population averages.
  • While weight-for-age and weight-for-height improved with age, height deficits persisted.
  • Weight gain was significantly associated with a slower yearly decline in FEV1 (1.8-1.9% decrease per unit increase in WFA/WFH).

Conclusions:

  • Pediatric CF patients aged 2-10 years demonstrate persistent growth impairment.
  • Interventions promoting weight gain can positively impact lung function trajectory in children with CF.
Abstract

Keywords:
Cystic fibrosisGrowthNutritional assessmentRespiratory function tests

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