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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: May 7, 2026

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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BRAF mutation in 'sarcomas': a possible method to detect de-differentiated melanomas.

Nicole A Cipriani1, Igor Letovanec, Francis J Hornicek

  • 1Department of Pathology, The University of Chicago, Chicago, IL, USA.

Histopathology
|October 15, 2013
PubMed
Summary

BRAF mutations are absent in sarcomas but can occur in undifferentiated pleomorphic sarcomas (UPS) that are also melanomas. BRAF testing may help diagnose de-differentiated melanoma in spindle cell malignancies.

Keywords:
BRAFNRASde-differentiated melanomamalignant fibrous histiocytomamelanomaundifferentiated pleomorphic sarcoma

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Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • BRAF mutations are common in melanoma (50-60%) but rarely studied in sarcomas.
  • Distinguishing undifferentiated spindle cell melanoma from sarcoma can be diagnostically challenging.
  • Undifferentiated pleomorphic sarcomas (UPS) can mimic melanoma morphologically.

Observation:

  • BRAF mutation analysis was performed on 104 spindle cell malignancies.
  • No BRAF mutations were found in 90 sarcoma-only cases.
  • Three sarcomas (all UPS) in patients with melanoma showed BRAF mutations, with one identical to the patient's melanoma V600E mutation.

Findings:

  • BRAF mutations were exclusively found in sarcomas co-occurring with melanoma, not in sarcoma-only cases.
  • The presence of BRAF mutation in UPS suggests a potential melanocytic origin.
  • Identical BRAF V600E mutations were observed in one melanoma-sarcoma pair.

Implications:

  • BRAF mutational status is a valuable tool for diagnosing spindle cell malignancies.
  • Positive BRAF mutation results in UPS may indicate de-differentiated melanoma.
  • Consider BRAF testing in spindle cell malignancies, especially with a history of melanoma.