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Lipid profile and atherogenic indices soon after birth in Japanese preterm infants

Hiromichi Shoji1, Yayoi Murano, Mari Mori

  • 1Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.

Acta Paediatrica (Oslo, Norway : 1992)
|October 15, 2013
PubMed

Insights

Prematurity and fetal growth restriction in newborns impact lipid metabolism, affecting early cardiovascular disease risk. These factors influence atherogenic indices measured at birth in preterm infants.

Area of Science:

  • Neonatal Medicine
  • Cardiovascular Research
  • Metabolic Studies

Background:

  • The intrauterine environment is a critical determinant of adult cardiovascular disease (CVD) risk.
  • Prematurity and fetal growth restriction are significant concerns in neonatal care.
  • Understanding early metabolic changes is key to preventing long-term health issues.

Purpose of the Study:

  • To investigate the impact of prematurity and fetal growth restriction on infant lipid metabolism.
  • To assess key atherogenic indices shortly after birth in preterm neonates.

Main Methods:

  • Blood samples were collected from 80 preterm infants (gestational age ≤35 weeks) within 20 minutes of birth.
  • Serum levels of total cholesterol (TC), LDLc, HDLc, apoA1, and apoB were measured.
  • Atherogenic ratios (TC/HDLc, LDLc/HDLc, apoB/apoA1) were calculated and correlated with gestational age and birth weight parameters.

Main Results:

  • Negative correlations were observed between gestational age, birth weight, and SD score for birth weight with TC/HDLc, LDLc/HDLc, and apoB/apoA1 ratios.
  • These findings suggest that reduced gestational age and poorer fetal growth are associated with less favorable lipid profiles at birth.

Conclusions:

  • Prematurity and suboptimal fetal growth appear to influence lipid and apolipoprotein metabolism in preterm infants.
  • Early assessment of atherogenic indices at birth may identify infants at higher risk for future cardiovascular complications.
Abstract

Keywords:
ApolipoproteinsFoetal growth restrictionLipoproteinsPreterm infants

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