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Updated: May 7, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Risk factors for acute kidney injury in patients undergoing same admission coronary angiography and valve replacement
Yijie Hu1, Zhiping Li, Jianming Chen
1Department of Cardiovascular Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Yuzhong District, Chongqing, China.
Insights
Diabetes and cerebrovascular disease significantly increase the risk of acute kidney injury (AKI) in patients undergoing same-admission coronary angiography and valve replacement. Caution is advised for these high-risk individuals.
Area of Science:
- Cardiology
- Nephrology
- Cardiovascular Surgery
Background:
- Investigated risk factors for acute kidney injury (AKI) in patients undergoing same-admission coronary angiography (CAG) and valve replacement.
- Examined a cohort of 283 patients undergoing valve surgery, with 71 included for analysis of preoperative CAG.
- Focused on the incidence and predictors of AKI in a specific surgical population.
Purpose of the Study:
- To identify risk factors for acute kidney injury (AKI) in patients undergoing combined coronary angiography and valve replacement.
- To determine the association between pre-existing conditions and AKI development post-procedure.
- To inform clinical practice regarding patient selection and procedural caution.
Main Methods:
- Univariable and multivariate logistic regression analyses were employed.
- Identified predictors of AKI using variables with p < 0.1 from univariable analysis and known AKI risk factors.
- Included 71 patients undergoing same-admission coronary angiography and valve replacement.
Main Results:
- Twenty-two (31.0%) patients developed AKI.
- Diabetes mellitus (OR 10.361) and cerebrovascular disease (OR 26.070) were identified as significant independent risk factors for AKI.
- Concomitant tricuspid valve repair/replacement and atrial fibrillation were risk factors in univariable analysis, but not significant in multivariate analysis.
Conclusions:
- Diabetes mellitus and cerebrovascular disease are significant risk factors for AKI in patients undergoing same-admission CAG and valve replacement.
- These procedures should be approached with caution in patients with diabetes and cerebrovascular disease.
- Further research may explore preventative strategies for AKI in this vulnerable patient group.
Background:
We investigated risk factors for acute kidney injury (AKI) in patients undergoing same admission coronary angiography (CAG) and valve replacement.
Methods:
Among 283 consecutive patients undergoing valve surgery between October 2010 and July 2012, 71 patients with same admission preoperative CAG were included in the study. Predictors of AKI were identified with a univariable model; then, logistic regression analysis was performed with the variables with p < 0.1 in univariable analysis and other known risk factors of AKI.
Results:
Twenty-two (31.0%) patients developed AKI. Univariate analysis revealed that diabetes mellitus (p = 0.097), cerebrovascular disease (p = 0.03), atrial fibrillation (p = 0.097), one-stage procedure (p = 0.05), and concomitant tricuspid valvular replacement/repair (p = 0.033) were risk factors. Multivariate logistic regression analysis showed that diabetes mellitus (odds ratio [OR] 10.361, 95% CI 1.345-79.828, p = 0.025) and cerebrovascular disease (OR 26.070, 95% CI 1.695-400.939, p = 0.019) are risk factors for AKI in patients 50 years or older undergoing same admission CAG and valve replacement. One-stage procedure was not associated with a higher incidence of AKI.
Conclusion:
Diabetes mellitus and cerebrovascular disease are risk factors for AKI. Same admission CAG and valve replacement should be performed with caution in this group of patients.
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